Details

Project TitleMouse Model for Endocrine Pancreatic Development, Insulin Secretion and Diabetes
Track Code2010-071
Short Description

(1) Identification of a new function for the clock transcription network in the regulation of endocrine pancreas development and glucose-stimulated insulin secretion
(2) Generation of an animal model with isolated abrogation of clock function within islet cells

Abstract

Northwestern researcher, Joseph Bass, created a mouse model based on removing the clock function within islet cells. These mice exhibit striking defects in insulin secretion which ultimately leads to greatly accelerated early life diabetes. This model provides a direct opportunity to apply new methods to study and understand how the clock transcription network regulates aspects of endocrine pancreas function. With this understanding, it provides the opportunity to explore various means of enhancing islet function and to further develop existing or potential therapies for diabetes, such as (1) stem cell therapies for type 1 diabetes, (2) cell survival in post-transplant and/or endogenous islet function in type 1 and 2 diabetes, and (3) pharmacotherapeutic targeting for enhanced insulin secretion in type 2 diabetes. In fact, the development of clock-modulators using this platform is already underway.

 
Tagsresearch tools, stem cells, animal models
 
Posted DateJan 31, 2012 4:19 PM

Inventor(s)

Joseph Bass

Biliana Marcheva

Applications

  • Research Tool: Animal Model
  • High throughput screening for diabetes-modifying therapeutics
  • Identification of methods using stem cell transplantation and cell preservation methods
  • Drug Discovery for improved combination treatments with existing agents

Advantages

Powerful tool to dissect the role of clock transcription network on endocrine pancreas function

Publications

Contact Information

Mike Moore, PhD  
Invention Manager  
(p) 847-491-4645 

(e) michaelmoore@northwestern.edu