Details

Project TitleModel for Urinary Bladder Regeneration Utilizing Adult Stem Cells
Track Code2010-150
Short Description

A non-human primate model for regenerating the bladder using adult stem cells.

#therapeutics #stemcells

Abstract

Northwestern researchers have developed a model for bladder regeneration using bone marrow stem and progenitor cells (BMSPCs). BMSPCs are non-exclusively comprised of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), both of which can be isolated from patients in a simple manner using cell surface markers and subsequently stimulated and expanded to large numbers using cytokines. This process leads to a terminal differentiation program in which these cells form functional vasculature, which addresses a fundamental problem with current regenerating bladder tissue. BM EPCs have been demonstrated in vivo to form functional vasculature that nourishes developing tissue. Furthermore, this technology also demonstrates the ability of a cell mixture of MSCs and/or EPCs in a thin-film scaffold to achieve enhanced tissue repair in an animal model of a damaged bladder.

 
TagsTHERAPEUTICS: stem cells
 
Posted DateNov 30, 2011 10:43 AM

Inventor(s)

Earl Cheng
Natalie Fuller
Derek Matoka
Arun Sharma
Matthew Bury

Andrew Marks

Applications

  • Tissue Repair for bladder regeneration

Advantages

  • Functional vascularization
  • Successful in vivo animal model

IP Status

Patent applications have been filed.

Contact Information

Michael Moore, PhD
Invention Manager
(p) (847) 491-4645

(e) michaelmoore@northwestern.edu