Details

Project TitleAssessment of Oocyte Quality by Inorganic Signatures
Track Code2010-048
Short Description

Development of a noninvasive, colorimetric assay for predicting embryo quality and oocyte fertilization.

#diagnostics #marker #therapeutics #fertility

Abstract

Northwestern researchers have developed a noninvasive, colorimetric assay for predicting embryo quality and oocyte fertilization. The assay relies on the occurrence of zinc sparks which are zinc secretion events that occur at fertilization. Currently, egg quality assessments for in vitro fertilization are based upon morphological parameters which are not entirely consistent or easily standardized. While spindle morphology can be noninvasively monitored with birefringence imaging, this particular technology is cost-prohibitive. The Northwestern investigators propose the use of colorimetric probes for zinc as a simple and cost-effective method to easily monitor fertilization and to assess the developmental potential of the embryo.

 
TagsTHERAPEUTICS: fertility, DIAGNOSTICS: marker
 
Posted DateNov 29, 2011 10:25 AM

Inventor(s)

Teresa K. Woodruff
Thomas V. O'Halloran

Emily Que

Alison Kim

Applications

in vitro fertilization

Advantages

• Noninvasive method
• Simple and Inexpensive
• Provides confirmation of fertilization
• Predicts developmental potential of resulting embryo

• No disruption of intracellular environment of egg

Publications

IP Status

A patent application has been filed.

Contact Information

Mike Moore, PhD

Invention Manager 

(p) 847-491-4645

(e) michaelmoore@northwestern.edu