Details

Project TitleSoft Biomaterials for 3D Printing for Tissue Engineering Applications
Track Code2013-152
Short Description

A multimaterial bio-ink for 3D printing of cross-linked, soft hydrogels that can be used in tissue engineering

#therapeutics #drug delivery #gene delivery #biomedical #manufacture/processes #materials

Abstract

Northwestern researchers have developed a novel bio-ink material for 3D printing that holds promise for various tissue engineering and drug delivery applications. Bioprinting techniques are often limited by a dearth of bio-inks that are extrudable and able to form self-supporting gels while being biocompatible, inexpensive and allow for one-step fabrication. Prof. Shah and colleagues have addressed these issues by using a safe, biocompatible crosslinker molecule (PEG) in their formulations for their 3D biomaterials. Their novel bio-ink can accommodate living cells, opening up new avenues for tissue engineering and production of implantable medical devices. Importantly, these bio-inks begin to form gels in the printing cartridge, so there is no need for an additional gelling step after the bio-ink is dispensed. No other bio-ink formulation accomplishes simultaneous extrusion and gelation, which could make this innovative material useful in the fields of tissue engineering and drug delivery.

 
Tagsbiomedical, MANUFACTURE/PROCESSES, MATERIALS: biomedical, THERAPEUTICS: drug delivery, THERAPEUTICS: gene therapy
 
Posted DateJun 12, 2015 5:27 PM

Inventor(s)

Alexandra Rutz

Ramille Shah*

Applications

  • Tissue engineering
  • Injectable cell-based therapies
  • Gene, protein and drug delivery
  • Research reagent for cell signaling studies

Advantages

  • Biocompatible and inexpensive materials
  • Simple fabrication set up
  • Extrudable and self-supporting gels
  • Tunable mechanical properties

Publications

IP Status

US and international patent applications have been filed.

Contact Information

Dimitra Georganopoulou, PhD

Invention Manager

(p) 847.467.3095

(e) d-georganopoulou@northwestern.edu