Details

Project TitleThermoresponsive Cell Adhesive Bioresorbable Dressing for Wound Healing Applications
Track Code2015-071
Short Description

Novel citrate-based thermoresponsive gel dressing that fosters cell adhesion to improve wound healing

#materials #biomedical #therapeutics #woundhealing

Abstract

Northwestern scientists have developed a polymer composite for wound dressing that facilitates cell recruitment and infiltration into the wound bed without the need for soluble factors. This novel bioresorbable dressing is functionalized with two peptides that attract specific cell populations into the wound to speed healing. Cell recruitment combined with the intrinsic antioxidant properties of the hydrogel dressing has the potential to alter treatment of both acute and chronic wounds (e.g. diabetic foot ulcers or bedsores). Importantly, this cell recruitment strategy does not depend on soluble factors, which are unstable and lose effectiveness over time, in other wound dressings. In laboratory studies with a mouse model for diabetic wound healing, this novel material significantly outperforms the non-functionalized polymer dressing. Finally, this new polymer composite can also be functionalized with other peptides to recruit specific cell populations for purposes of bone or vascular regeneration.

 
TagsMATERIALS: biomedical, THERAPEUTICS: wound healing
 
Posted DateJun 12, 2015 4:56 PM

Inventor(s)

Guillermo Ameer*

Yunxiao Zhu

Zdravka Cankova

Milan Mrksich

Applications

  • Wound healing (e.g. diabetic wound healing, bed sores)
  • Localized delivery of cell-based therapies
  • Bone or vascular regeneration

Advantages

  • Intrinsic antioxidant properties
  • Increased wound closure rate
  • Versatile

Publications

Zhu Y, Hoshi R, Chen S, Yi J, Duan C, Galiano R, Zhang H, Ameer G (2016).  Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes. J Control Release. 238: 114-22.

IP Status

Provisional and PCT patent applications have been filed.

Contact Information

Dimitra Georganopoulou, PhD

Invention Manager

(p) 847.467.3095

(e) d-georganopoulou@northwestern.edu