Project TitleG-Protein Inhibitors for Treatment of Atrial Fibrillation
Track Code2007-044
Short Description

Treatment for atrial fibrillation (AF) by modulation of nerves in the heart muscle using inhibitors of G protein signaling



In collaboration with industry partners, a scientist from Northwestern University has developed a novel strategy for treating atrial fibrillation (AF). Their innovative approach relies on modulating the autonomic nervous system in the heart using G protein inhibiting peptides, which enter the heart muscle and interrupt the aberrant signaling. Given that AF is the most common heart rhythm disorder, developing novel treatment modalities is imperative. In laboratory studies performed to date, G protein inhibiting peptides could be delivered by injection to selectively inhibit AF formation. This invention holds promise for development into a therapetic for AF, but may also contribute to G protein signaling and autonomic nervous system research fields.

Posted DateJun 1, 2015 12:52 PM


Rishi Arora*

Alan Kadish

Annette Gilchrist


  • Treatment of AF
  • Research tool for G protein signaling


  • Selective
  • Potential for personalized AF therapy


IP Status

Issued US patents 8,193,151 and 8,518,884

Contact Information

Michael Moore, PhD

Invention Manager

(p) 847.491.4645