Details

Project TitleAntibody Against the PAD Region of Tau
Track Code2012-050
Short Description

Mouse monoclonal antibody recognizes the PAD region of human Tau protein

#researchtool #antibody

Abstract

Northwestern researchers have generated a novel antibody against the PAD domain of Tau protein, which becomes exposed as Tau aggregates. Tau protein aggregation is a pathological hallmark of Alzheimer's Disease (AD), which ultimately leads to neuron degeneration. This novel monoclonal antibody against the PAD domain allows tracking of Tau aggregation levels as a function of PAD domain exposure. The range of research efforts in the field of AD and other Tau-related brain disorders could be expanded with this new reagent. Further, this antibody could form a basis of an early detection diagnostic strategy for AD.

 
Tagsresearch tool: antibody
 
Posted DateJun 1, 2015 12:00 PM

Inventor(s)

Lester Binder*

Nicholas Kanaan

Yifan Fu

Applications

  • Research tool
  • Diagnostic tool for Alzheimer’s disease

Advantages

  • Detects an early event in Alzheimer’s disease pathogenesis
  • Specificity for Tau aggregates

Publications

IP Status

Contact Information

Michael Moore, PhD

Invention Manager

(p) 847.491.4645

(e) michaelmoore@northwestern.edu