Details

Project TitleA Genetic Marker for ALS
Track Code2013-046
Short Description

Novel diagnostic biomarker for amyotrophic lateral sclerosis (ALS)

#CNS #ALS #therapeutics #biomarker #diagnostic #marker

Abstract

Northwestern researchers have identified a novel gene, SQSTM1, for potential use in development of diagnostic tools for ALS. Presently, patients are diagnosed based on clinical, electrophysiological and pathological features, which are typically difficult and time-consuming practices. In their recent study, Prof. Siddique and colleagues identified ten different mutations in SQSTM1 that are associated with both sporadic and familial forms of ALS. This enhanced understanding of the genetics behind ALS offers opportunities to design molecular diagnostic tools that are both faster and more specific. Furthermore, since SQSTM1 protein is involved in protein recycling and autophagy, this discovery could also further rational drug design efforts aimed at curing or treating ALS.

 
TagsCNS: ALS, DIAGNOSTICS: marker, THERAPEUTICS: biomarker
 
Posted DateApr 29, 2015 10:48 AM

Inventor(s)

Faisal Fecto

Teepu Siddique*

Applications

  • Molecular diagnostic for ALS
  • ALS therapeutic discovery

Advantages

  • Increased specificity
  • Faster turn-around

Publications

IP Status

US patent application has been filed.

Contact Information

Michael Moore, PhD

Invention Manager

(p) 847.491.4645

(e) michaelmoore@northwestern.edu