Details

Project Title3-D Transfected Cell Arrays for High Throughput Transcriptional Profiling
Track Code2005-127, 2005-130, 2009-101, 2009-104
Short Description

Novel method for investigating gene regulation via transcriptional profiling #healthcare #diagnostictool #therapeutics #drugdiscovery #researchtool #method

Abstract

Northwestern scientists have developed a high throughput method for investigating gene transcription under various conditions. To achieve this, they designed a 3D hydrogel platform within which cells can be seeded and observed over time. This innovative system allows for high throughput screening of multiple transcription factors at once in a rapid and quantitative manner. In laboratory settings, this 3D cell array can be generated using a variety of cell types, which opens up the possibility that patient samples could be studied in-depth via this method. For example, samples from cancer patients could be investigated for drug sensitivity or for accurate disease tracking and diagnosis. This invention represents a step forward for tissue engineering research, but could also be adapted for use as a sensor for environmental toxins or biological warfare agents.

 
TagsHEALTHCARE: Diagnostic Tool, RESEARCH TOOL: method, THERAPEUTICS: drug discovery
 
Posted DateApr 21, 2015 11:57 AM

Inventor(s)

Angela K. Pannier

Abigail D. Bellis

Michael S. Weiss

Eric A. Ariazi

V. Craig Jordan

Julie Wieland

Lonnie Shea*

Applications

  • Diagnostic tool for cancer
  • Sensor for environmental toxins and biological warfare agents
  • Tissue engineering
  • Research tool for cell signaling

Advantages

  • High throughput
  • Quantitative
  • Rapid data acquisition

Publications

IP Status

US application has been filed.

Marketing Contact

Michael Moore, PhD

Invention Manager

(p) 847.491.4645

(e) michaelmoore@northwestern.edu