Details

Project TitleMacromolecular MRI Contrast Agents
Track Code2007-122
Short Description

Simple method to generate high molecular weight contrast agents with multiple gadolinium complexes for cellular imaging studies and clinical use

#healthcare #imaging #MRI #researchtool #method #reagent

Abstract

Northwestern University scientists have developed a novel method to generate contrast agents for magnetic resonance imaging that contain multiple gadolinium (Gd) complexes. Many researchers avoid using Gd-based contrast agents because of their lack of sensitivity compared to current alternatives. The innovative method for generating highly sensitive Gd-containing contrast agents from the Meade Lab employs click chemistry to produce large molecular weight compounds with 3-7 Gd complexes. Each Gd ion is covalently linked to the rest of the molecule, which ensures the longevity of this reagent in vivo. Furthermore, these novel reagents are biocompatible, easily taken up by cells and inexpensive to produce. With their many favorable traits, these new contrast agents could be useful in  both the clinical and research arenas.

 
TagsHEALTHCARE: imaging, HEALTHCARE: MRI, RESEARCH TOOL: method, research tool: reagent
 
Posted DateMar 17, 2015 5:22 PM

Inventor(s)

Ying Song

Ellen Kohlmeir

Thomas J Meade*

Applications

  • Magnetic resonance imaging
  • Research tool for cell imaging studies in vitro and in vivo

Advantages

  • Easy to synthesize
  • Cost-effective
  • Biocompatible
  • Increased contrast

Publications

IP Status

Issued US patent number 8,545,813

Marketing Contact

Zach Brown, PhD

Invention Associate

(p) 847.491.4629

(e) Zachary.Brown@northwestern.edu