Details

Project TitleNanostructures for Diagnosis and Therapy of Alzheimer's Disease
Track Code2009-169
Short Description

Novel magnetic nanostructures that recognize toxic β-amyloid protein oligomers responsible for Alzheimer's disease progression

#therapeutics #biomarker #healthcare #diagnostictool #CNS #Alzheimersdisease #nanotechnology #nanoparticles

Abstract

Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and destroy β-amyloid protein oligomers, which are a hallmark of Alzheimer's disease. The magnetic nanostructures can be used for imaging, as the nanoparticle acts as an MRI contrast agent. Furthermore, the nanoparticles can be activated by exposure to radiofrequency, and have been shown to release heat and inactivate the β-amyloid oligomers without damage to the neurons. The antibody conjugated to the nanoparticle confers the specificity of the nanostructures. Therefore, this same therapeutic and diagnostic method could be applied to other diseases with the modification of the antibody type. Most importantly, the nanostructures can be synthesized in a single step process, which makes them an extremely attractive diagnostic and therapeutic reagent.

 
TagsTHERAPEUTICS: biomarker, HEALTHCARE: Diagnostic Tool, CNS: Alzheimer's Disease, THERAPEUTICS: CNS, nanotechnology: nanoparticles
 
Posted DateMar 13, 2015 3:45 PM

Inventor(s)

Vinayak Dravid

Saurabh Sharma

Kristen Viola

William Klein

Applications

  • Thermal activation therapy for AD
  • Imaging for AD diagnosis
  • Imaging and therapy for other CNS disorders

Advantages

  • Non-invasive imaging procedure
  • Combined therapeutic and diagnostic modalities
  • Specific for amyloid oligomers
  • Simple to synthesize

Publications

IP Status

US patent application has been filed for this invention.

Contact Information

Arjan Quist, PhD

Invention Associate 

(p) 847-467-0305 

(e) arjan.quist@northwestern.edu