Details

Project TitleTransgenic Model Of Fibrodisplasia Ossificans Progressiva (FOP)
Track Code2007-076
Short Description

New mouse model of FOP, a rare genetic disease characterized by abnormal growth of bone which replaces soft tissues

 #researchtool #animalmodel 

Abstract

Northwestern University scientists developed a mouse model of fibrodisplasia ossificans progressiva (FOP), a rare genetic disease that causes soft tissues to be replaced with bone over time. While it was understood that bone morphogenetic protein-4 (BMP-4) was involved in the pathophysiology of this disease, this knowledge did not facilitate the generation of a good mouse model of FOP for many years. Northwestern researchers were able to generate a transgenic mouse model that most closely mimics human disease by overexpressing BMP-4 under the control of the neuron specific enolase (NSE) promoter. This model was used to confirm the role of BMP-4 in FOP and could enable further research that may lead to the development of a treatment for this disabling disease. 

 
Tagsresearch tool: animal model
 
Posted DateMar 6, 2015 5:38 PM

Inventor(s)

John A. Kessler

Applications

  • Study of FOP
  • Research of BMP signaling pathway

Advantages

  • Closely approximates human FOP disease

Publications

IP Status

Marketing Contact

Gwendolyn Humphreys, PhD

Invention Associate

(p) (847) 467-0308

(e) gwendolyn.humphreys@northwestern.edu