Details

Project TitleAntibody Against Vascular Endothelial Cells
Track Code1991-038
Short Description

 Monoclonal antibody for detection of human rheumatoid cells 

#researchtool #antibody #reagent

Abstract

A Northwestern University researcher discovered a differentially regulated antigen on the surface of endothelial cells that is associated with allergic contact dermatitis. The monoclonal mouse antibody developed against this antigen reacts with vascular endothelial cells in lymphoid tissues and endothelial cells in diseased tissue such as rheumatoid and osteoarthritic synovium, psoriatic skin, adrenal tumors and cutaneous Kaposi's sarcomas. It does not react with several myeloid or lymphoid cell lines, peripheral blood cells and platelets. Additionally, this antibody does not detect endothelium of medium-sized vessels and that of normal tissues such as liver and spleen. Therefore, this antibody can a useful reagent to distinguish between endothelial cells from normal and diseased tissue samples. 

 
Tagsresearch tool: antibody, research tool: reagent
 
Posted DateMar 6, 2015 5:31 PM

Inventor(s)

Alisa Koch

Applications

  • Research reagent

Advantages

  • Validated for immunohistochemistry experiments

Publications

IP Status

Marketing Contact

Gwendolyn Humphreys, PhD

Invention Associate

(p) 847-467-0308

(e) gwendolyn.humphreys@northwestern.edu