Project TitleHydrogel Bioadhesive with Multiple Crosslinking Mechanisms
Track Code2012-034
Short Description

Novel extra strong hydrogel adhesive for tissue repair applications 

#materials #biomedical


Materials with bioadhesive properties have a wide range of applications in the clinical arena. However, most of these materials are either not strong enough or exhibit some toxicity. Northwestern University researchers have developed a new, two-component hydrogel adhesive that addresses these two issues. This material owes its strength to multiple types of chemical crosslinks that are induced when the gel is formed. In addition, these crosslinks can be formed between the polymer and proteins in the tissue itself, giving it additional cohesive properties. Furthermore, the gel forms in under a minute at physiological conditions, making it a practical choice for use in a variety of medical situations. Once the gel is formed, it exhibits minimal equilibrium swelling of less then 5%, which also improves the strength of this novel polymer. Due to the ability to polymerize under mild, physiological conditions, this new hydrogel adhesive from the Messersmith group, will also find applications in development of cell-based therapies and drug delivery platforms. 

TagsMATERIALS: biomedical
Posted DateJan 29, 2015 10:36 AM


Iossif A Strehin

Devin G Barrett

Phillip B Messersmith*


  • Bioadhesive
  • Sealant
  • Tissue repair
  • Drug delivery
  • Cell delivery


  • Improved mechanical and adhesive properties though multiple cross linking mechanisms
  • Wide range of stiffness
  • Mild cross-linking conditions
  • Self-healing


IP Status

US and international patent applications have been filed.

Contact Information

Vara Josyula, PhD

Invention Manager 

(p) 847.491.4456