Project TitleCardiac Stress Test with MRI
Track Code2011-024
Short Description

An innovative approach to improve quantification of myocardial perfusion and cardiac flow reserve using MRI. #healthcare #mri #diagnostictool 


Northwestern researchers have developed a means to quantify myocardial perfusion and cardiac flow reserve (CFR) with magnetic resonance imaging (MRI). This approach is non-invasive and utilizes administration of a newer intravascular contrast agent that shortens T1 slows the leakage of the agent into the extra-vascular space. Mycocardial blood volume (MBV) is quantified by T1 changes following administration of the IV contrast agent. The group has devised an algorithm to correct for water exchange to more accurately quantify MBV. The Bookend technique can also be used to correct the first-pass contrast curve. The invention encompasses new imaging metrics, a novel pulse sequence, and a mathematical model to improve CFR imaging with MRI. The new approach may offer improved assessment of patients with multi-vessel coronary artery disease (CAD) to help identify the optimal therapeutic strategy. 

Posted DateJul 2, 2014 12:06 PM


Timothy J. Carroll* 
James Carr 
Octavia Biris 

Neil Chatterjee 


  • Diagnosis of single and multi-vessel coronary artery disease 
  • Diagnosis and management of patients presenting with non-specific chest pain 


  • Does not require cardiac catheterization or other invasive techniques 
  • Ability to generate reproducible pre- and post-treatment perfusion scans of patients with CAD to assess treatment effectiveness 
  • Provides reliable myocardial blood volume measures 


IP Status

A patent application has been filed. 

Contact Information

Dimitra Georganopoulou, PhD
Invention Manager
(p) 847-467-3095