Project TitlePotent and Selective Conformationally Restricted Dipeptide Inhibitors against nNos.
Track Code2001-057
Short Description

A portfolio of neuronal nitric oxide synthase inhibitors for use in treating neurodegenerative disorders. #therapeutics #CNS #alzheimer's #parkinson's #huntington's #smallmolecule


Northwestern researchers have created a diverse portfolio of neuronal nitric oxide synthase (nNOS) inhibitors. These inhibitors are potent, selective and able to permeate the blood-brain barrier. These small molecules include enhanced chemical compositions, such as those created by heteroaromatic selection, aminopyridine dimers, chiral pyrrolidine cores, azole rings that facilitate heme binding, intramolecular hydrogen bonding, and thiophene-2-carboximidamide-based compounds. The methods for synthesis as well as the small molecules are patented or have patent applications under review. Specific information on the individual compositions is available on request.

TagsTHERAPEUTICS: CNS, CNS: Alzheimer's Disease, CNS: Parkinson's Disease, CNS: Huntington's Disease, THERAPEUTICS: small molecule
Posted DateJun 12, 2014 4:33 PM


Richard B. Silverman,* Hui Huang, Henry Qingwei Zhang, Erik Erdal, Jose Antonio Gomez Vidal, Jung-Mi Hah, Mark Flinspach, Haitao Mark Ji, Huiying Li Thomas L. Poulos, Graham R. Lawton, Fengtian Xue, James M Kraus He Huang, Qing Jing


  • Therapeutic for neurological disorders, such as: 
    • Stroke
    • Schizophrenia
    • Migraine Headaches
    • Cerebral Ischemia
    • Long-Term Depression
  • Therapy for neurodegenerative disorders, such as Huntington's disease, Parkinson's disease and Alzheimer's disease
  • Potential for use in other disorders where nNOS is a therapeutic target


  • Variety of chemical compositions
  • Potent
  • Selective
  • Bioavailable
  • Permeate the blood-brain barrier
  • Selectivity results in reduced side effects compared to general NOS inhibitors

Inventions in this portfolio

NU 2001-036, 2001-057, 2003-083, 2005-128, 2008-172, 2008-179, 2009-024, 2009-164, 2010-008, 2010-075, 2011-053, 2012-112, 2012-146, 2013-020, 2014-101


IP Status

Issued U.S. Patents: 6,803,486; 6,274,5577,470,815; 8,158,658; 7,470,790; 7,994,326; 8,299,100; 8,278,084; 8,389,731; 8,618,143; 8,697,879; 8,557,552; 8,735,606.

Additional US patent applications have been filed.

International patent applications have also been filed.

Contact Information

Vara Josyula, PhD
Invention Manager
(p) 847.491.4456