Details

Project TitleNew Peptide Amphiphiles Bearing the Laminin Peptide Sequence IKVAV with Ability to Promote Neurite Outgrowth
Track Code2010-183
Short Description

Novel peptides that promote neurite growth with therapeutic applications. #therapeutics #cns #peptide 

Abstract

Northwestern researchers have created improved peptide amphiphiles bearing the laminin sequence IKVAV that promote neurite outgrowth. Synthesis and purification of these peptide amphiphiles is easier than with previous methods. In addition, these peptides are more soluble in salt solutions that mimic human extracellular fluids. Previous, similar amphiphiles demonstrated the ability to differentiate neuronal progenitors into neurons, promote neurite outgrowth, and reduce differentiation into astrocytes.

 
TagsTHERAPEUTICS: CNS, THERAPEUTICS: peptide
 
Posted DateMay 29, 2014 11:57 AM

Inventor(s)

Joshua Goldberger 
Eric J. Berns 
Samuel I. Stupp*

Applications

  • Injectable therapy for acute spinal cord injury 
  • Component of a scaffold for chronic spinal cord injury 
  • Peripheral nerve regeneration -Therapies that promote differentiation of neuronal progenitors or stem cells for neuron replacement 

Advantages

  • Improved synthesis and purification 
  • Improved solubility in salt solutions similar to extracellular fluids 

Publications

IP Status

A patent application has been filed. 

Contact Information

Michael Moore, PhD 
Invention Manager 
(p) (847) 491-4645 

(e) michaelmoore@northwestern.edu