Project TitleA Strategy for Attenuated-live Vaccines for Bacterial Infections
Track Code2008-004
Short Description

A novel method to treat urinary tract infection using attenuated-live vaccines.

#therapeutics #diseasemodel #vaccine


Urinary tract infections, either chronic or acute, are a frequent health problem in a variety of populations. Northwestern investigators have demonstrated that deletion of a certain gene from urinary-tract colonizing bacteria has resulted in a strain that promotes immune response when administered to mammalian subjects. The modified bacterium does not establish a persistent population in the bladder, but promotes cytokine secretion from urothelial cells. These bacteria represent a candidate material for a live-attenuated vaccine that could be used to protect against acute and recurrent urinary tract infections. Successful tests have been performed in a mouse model.

TagsTHERAPEUTICS: disease model, THERAPEUTICS: vaccine
Posted DateMay 31, 2013 12:08 PM


Anthony J. Schaeffer*
David J. Klumpp

Benjamin Billips


• Preventative medicine for UTIs
• Alternative to repeated use of antibiotics

• Particularly useful for nursing home patients or other high-risk groups


• Prevents infection by stimulating patient immune system
• Inexpensive, easy-to-grow bacterium

• Simple to administer


IP Status

A patent application has been filed.

Contact Information

Michael Moore, PhD
Invention Manager
(p) 847-491-4645