Details

Project TitleTransgenic Mouse Model Exhibiting Physiological and Behavioral Defects due to Disruption in Circadian Rhythm
Track Code1994-026
Short Description

Transgenic mouse model for circadian rhythm

#circadianrhythm #researchtool #animalmodel

Abstract

Northwestern researchers have a well-developed transgenic mouse model containing a clock defective gene. Based on their previous work, they had identified the clock gene as a regulator of machinery controlling the biological clock. They found that the clock defective mice exhibit a circadian period that is elongated by 4 hours followed by a complete loss of circadian rhythm in constant conditions. With this mouse model, they have already begun extensive work supporting the importance of the clock function beyond circadian rhythm. For example, they found that the these mice exhibit significant changes in various physiological and behavioral functions, including obesity and glucose tolerance, reproduction, response to chemotherapeutic agents, drug addiction, and sleep-related disorders. This animal model is a useful tool to further study these various biological processes in vivo and help identify effective therapies. cDNA clones of the wild-type mouse and human clock genes are also available.

 
Tagsresearch tool: animal model
 
Posted DateFeb 19, 2013 11:58 AM

Inventor(s)

Joseph Takahashi
Lawrence Pinto
Fred Turek
William Dove

Applications

Transgenic Mouse Model for understanding Circadian Rhythm and identifying sleep disorder related therapies

Advantages

• Exhibits significant physiological and behavioral changes
• In vivo tool for effective therapies

Publications

IP Status

Contact Information

Gwendolyn Humphreys, PhD

Invention Associate

(p) 847.467.0308
(e) gwendolyn.humphreys@northwestern.edu