Details

Project TitleTransgenic Mice Expressing Superoxide Dismutase (SOD)
Track Code1994-011
Short Description

Development of a unique transgenic mouse model that expresses superoxide dismutase

Abstract

Northwestern researchers have developed a transgenic mouse model expressing a mutant allele of human superoxide dismutase (SOD) with a Gly93 to Ala93 substitution. The Cu, Zn SOD expressing animals develops clinical features reminiscent of familial amyotrophic lateral sclerosis (ALS). Due to loss of motor neurons in the spinal cord, these hemizygous transgenic mice exhibit rapid motor degeneration and become paralyzed in their limbs and ultimately die within four to five months. This mouse model has already been widely used for screening therapeutic candidates for the discovery of drugs to treat ALS. This is an excellent animal model for the analysis of Cu- or Zn-superoxide dismutase in ALS, also known as Lou Gehrig's disease.

 
TagsCNS: ALS, research tool: animal model
 
Posted DateFeb 12, 2013 3:29 PM

Inventor(s)

Teepu Siddique*
Haifeng Pu Eishingdrelo

Mark Gurney

Applications

  • Drug Screening for ALS
  • Research Tool: Mouse model for Superoxide Dismutase & ALS

Advantages

  • Unique in vivo model
  • Widely Used

Publications

IP Status

Northwestern is interested to have this mouse model utilized for the development of therapeutics to treat ALS and other disease associated with mutations in Cu, Zn SOD. This mouse model is available for licensing.

Contact Information

Gwendolyn Humphreys, PhD

Invention Associate 

(p) (847) 467-0308 

(e) gwendolyn.humphreys@northwestern.edu