Project TitleAssembly of Nanoparticles for Synergistic Photothermal-Mediated Diagnosis and Therapy
Track Code2011-044
Short Description

A biomimetic strategy to create surface-derivatized metal nanoparticles

#healthcare #diagnostictool #nanotechnology #nanoparticles


Northwestern researchers have developed a catechol redox-based strategy to induce spontaneous in situ formation of polymer-coated gold and silver nanoparticles from mixtures of a DOPA-containing polymer and noble metal salts. In this biomimetic strategy, the catechol side chain of DOPA serves multiple roles: (1) a reducing agent for metal ions; (2) an anchoring chemistry for multivalent binding of the polymer onto the nanoparticle surface; and (3) a chemical precursor for cross-linking of the polymer shell. The resulting core−shell nanoparticles exhibit plasmon resonance behavior characteristic of noble metal nanoparticles and are stable toward aggregation in ionic aqueous media. This biomimetic strategy may be used to produce surface-derivatized metal nanoparticles for either diagnostic or therapeutic applications.

TagsHEALTHCARE: Diagnostic Tool, nanotechnology: nanoparticles
Posted DateJan 31, 2012 3:48 PM


Kvar Black
Phillip B Messersmith*
Jose Rivera

Ji Yi


Diagnostic and Therapeutic Imaging


  • Biomimetic strategy
  • Stable in media
  • Plasmon resonance behavior characteristic of noble metal nanoparticles


IP Status

Issued U.S. Patent No. 8,784,895

Contact Information

Vara Josyula, PhD 
Invention Manager  
(p) 847-491-4456