Details

Project TitleSelf-Assembled Bioadhesives
Track Code2013-114
Short Description

New class of DOPA-containing self-assembling peptides with various biological applications

#nanotechnology #nanoparticles #materials #biomedical #adhesives

Abstract

Mussels owe their incredible adhesion ability to the presence of an unusual amino acid found in its adhesive proteins, called DOPA, which has inspired many material scientists to emulate and improve bioadhesives. Recently, a new DOPA-containing peptide has been generated through collaboration of a group of international scientists. They improved the previously known DOPA-containing peptides by introducing several modifications that now enable self-assembly and increase the number reactive groups in an orderly fashion. The new materials can be functionalized to introduce properties having an ordered structure with controlled orientation of adhesive sites. The micro- and nano-structures of the present invention provide superior adhesive properties versus known bioadhesive polymers. Furthermore, these DOPA-containing polymers can incorporate silver ions forming a silver-coated hydrogels with antimicrobial applications. The novel materials are biocompatible with utility in a variety of pharmaceutical, cosmetic and medical device applications. 

 
TagsMATERIALS: adhesives, MATERIALS: biomedical, nanotechnology: nanoparticles
 
Posted DateFeb 2, 2015 10:48 AM

Inventors

Galit Fichman

Lihi Adler-Abramovich

Ehud Gazit

Phillip B. Messersmith*

Applications

  • Silver ion reduction
  • Coatings for medical devices
  • Tissue adhesive
  • Templating of inorganic materials onto organic ones

Advantages

  • Self-assembling
  • High density of reactive groups

Publications

Fichman G, Adler-Abramovich L, Manohar S, Mironi-Harpaz I, Guterman T, Seliktar D, Messersmth PB, Gazit E (2014). Seamless Metallic Coating and Surface Adhesion of Self-Assembled Bioinspired Nanostructures Based on Di-(3,4-dihydroxy-L-phenylalanine) Peptide Motif, ACS Nano. 8: 7220- 7228.

IP Status

US and international patent applications have been filed.

Contact Information

Vara Prasad V.N. Josyula, PhD

Invention Manager

(t) 847.491.4456

(e) vara.josyula@northwestern.edu