Details

Project TitleMethods for generating substituted imidazole molecules
Track Code2013-003
Short Description

Improved method for producing substituted imidazoles, key biologically active compounds used against a variety of diseases

#chemical #methods # medicinal 

Abstract

Substituted imidazoles are a privileged structural motif present in small molecules active against HIV, depression and inflammation. Methods for producing these types of molecules are rarely reported, indicating there is a high degree of difficulty involved in these processes. Northwestern University researchers have developed a novel method for producing substituted imidazoles with various functional groups. Their method is simple, efficient and can be used with a variety of functional groups to produce a large variety of compounds. Furthermore, this method can be applied to synthesizing novel amino acids by introducing new functional groups onto a glutamic acid scaffold. This novel class of compounds could have a large variety of biological functions and find many applications in the field of drug development. 

 
TagsCHEMICAL: methods, CHEMICAL: medicinal
 
Posted DateJan 23, 2015 3:12 PM

Inventor(s)

Karl A. Scheidt*

Elizabeth A. O’Bryan

Applications

  • Anti-inflammatory, anti-depressant, anti-viral drugs
  • New amino acid derivatives

Advantages

  • Operationally simple reaction
  • High yield with excellent enantioselectivity
  • Large number (over 15) of functional groups is tolerated

Publications

IP Status

Issued US patent 8,912,341

Marketing Contact

Allan Nader, PhD 

Invention Manager 

(e) a-nader@northwestern.edu

(p) 847.491.4456